Immunogenicity of a bovine rotavirus glycoprotein fragment

Immunogenicity of a bovine rotavirus glycoprotein fragment.

Previous experiments demonstrated that an antigenic site responsible for virus neutralization and cell attachment was located on a 14,000-molecular-weight fragment of the major bovine rotavirus (BRV) glycoprotein (M. Sabara, J. E. Gilchrist, G. R. Hudson, and L. A. Babiuk, J. Virol. 53:58-66, 1985). However, it was necessary to investigate whether this fragment also had the ability to induce th...

HIV-1 Glycoprotein Immunogenicity

A definition of bovine rotavirus virulence.

Rotaviruses are accepted as enteric pathogens of calves but many natural infections are subclinical. In the present paper, the outcome of inoculation of gnotobiotic calves of three ages (the second day of life, the second week of life and calves aged 6 weeks and over) with doses of 10(5.0) to 10(6.5) TCID50 was compared for three bovine rotavirus isolates (C3-160, 17/4 and 39/58). The clinical ...

Nucleotide sequence of the gene encoding the serotype-specific glycoprotein of UK bovine rotavirus.

The nucleotide sequence of the gene which encodes the major outer-shell glycoprotein of UK bovine rotavirus has been determined. The dsRNA genome segment encoding this protein was converted into ds cDNA and cloned into pBR322 for sequence studies. The gene is 1062 base pairs in length and contains a single, long, open reading-frame capable of coding for a protein of 326 amino-acids. This would ...

Recombinant Glycoprotein Ibat Fragment

The platelet GP Ib-IX receptor supports platelet adhesion and activation by binding to vWf in the exposed subendothelial matrix. An abnormal GP Ib-IX complex exists in platelet-type or pseudo-von Willebrand disease and has a characteristic increased affinity for soluble vWf resulting in impaired hemostatic function due to the removal of larger vWf multimers from the circulation. Genetic studies...